What is the treatment for syphilis?

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Multiple Choice

What is the treatment for syphilis?

Explanation:
Penicillin G is the treatment of choice for syphilis because it reliably eradicates Treponema pallidum and has the strongest evidence of effectiveness across all stages. For early syphilis, a single dose of benzathine penicillin G often cures the infection; for late latent or tertiary disease, a longer course with weekly doses is used; and for neurosyphilis, high‑dose intravenous penicillin G is required to achieve adequate central nervous system levels. While alternatives like doxycycline or amoxicillin can be considered in penicillin-allergic patients, they are not as reliably effective, and azithromycin resistance in Treponema pallidum limits its use.

Penicillin G is the treatment of choice for syphilis because it reliably eradicates Treponema pallidum and has the strongest evidence of effectiveness across all stages. For early syphilis, a single dose of benzathine penicillin G often cures the infection; for late latent or tertiary disease, a longer course with weekly doses is used; and for neurosyphilis, high‑dose intravenous penicillin G is required to achieve adequate central nervous system levels. While alternatives like doxycycline or amoxicillin can be considered in penicillin-allergic patients, they are not as reliably effective, and azithromycin resistance in Treponema pallidum limits its use.

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