Which of the following is a contraindication for the Rotavirus vaccine?

• A. Seasonal allergies
• B. Mild immunodeficiency
• C. Severe immunodeficiency, HIV/AIDS, cancer, steroid therapy
• D. Diabetes mellitus

Answer: (C)

Rotavirus vaccine is a live attenuated oral vaccine, so it is avoided in people with significant immune system compromise. The key risk is that a live vaccine can cause disease in individuals whose immune defenses are not strong enough to contain the weakened virus. Severe immunodeficiency—including conditions like HIV/AIDS with marked immunosuppression, cancer with immunosuppression, or ongoing systemic steroid therapy—greatly increases that risk, making it a contraindication.

Seasonal allergies or diabetes mellitus do not by themselves prevent rotavirus vaccination, and mild immunodeficiency is not considered a contraindication in this context.